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CCSB researchers created a map linking different diseases, represented by circles, to the genes they have in common, represented by squares.
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NHGRI Funds Two Centers of Excellence in Genomic Science |
The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), today announced grants expected to total approximately $30 million to establish one new Center of Excellence in Genomic Science at the Dana-Farber Cancer Institute (DFCI), and continue its support of the center at Stanford University.
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Miguel Angel Pujana, Jing-Dong J Han, Lea M Starita, Kristen N Stevens, Muneesh Tewari, Jin Sook Ahn, Gad Rennert, Victor Moreno, Tomas Kirchhoff, Bert Gold, Volker Assmann, Wael M ElShamy, Jean-Francois Rual, Douglas Levine, Laura S Rozek,Rebecca S Gelman, Kristin C Gunsalus, Roger A Greenberg, Bijan Sobhian, Nicolas Bertin, Kavitha Venkatesan, Nono Ayivi-Guedehoussou, Xavier Sole, Pilar Hernandez, Conxi Lazaro, Katherine L Nathanson, Barbara L Weber, Michael E Cusick, David E Hill, Kenneth Offit,David M Livingston, Stephen B Gruber, Jeffrey D Parvin & Marc Vidal
Network modeling links breast cancer susceptibility and centrosome dysfunction.
Nat Genetics 2007 39:1338-49.
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Preview, Cancer Cell
Highlight, Nature Reviews Genetics
Highlight, Nature Reviews Cancer
DFCI News |
Many cancer-associated genes remain to be identified to clarify the underlying molecular mechanisms of cancer susceptibility and progression. Better understanding is also required of how mutations in cancer genes affect their products in the context of complex cellular networks. Here we have used a network modeling strategy to identify genes potentially associated with higher risk of breast cancer. Starting with four known genes encoding tumor suppressors of breast cancer, we combined gene expression profiling with functional genomic and proteomic (or ‘omic’) data from various species to generate a network containing 118 genes linked by 866 potential functional associations. This network shows higher connectivity than expected by chance, suggesting that its components function in biologically related pathways. One of the components of the network is HMMR, encoding a centrosome subunit, for which we demonstrate previously unknown functional associations with the breast cancer– associated gene BRCA1. Two case-control studies of incident breast cancer indicate that the HMMR locus is associated with higher risk of breast cancer in humans. Our network modeling strategy should be useful for the discovery of additional cancerassociated genes. MORE->>> |
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Center for Cancer Systems Biology (CCSB)
Presents
Title is TBA
Sara Cherry , Ph.D.
University of Pennsylvania School of Medicine
Thursday May 29, 2008
2:00 PM
Dana 1620
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