| Integration of Oncogenic Networks in Cancer Phenotypes Integrated Cancer Biology Program at Duke is one of the NCI funded cancer systems biology programs and represents a collaboration that combines biological and analytic resources and expertise at Duke University, the Dana Farber Cancer Institute, Arizona State University, and the University of Southern California. The Duke ICBP (DICBP) is developing data and computational tools focused on an integrative and in-depth understanding of cell signaling pathways that are central to the control of cell proliferation and the oncogenic process. This core biological context - interconnected oncogenic signaling pathways including the Ras, Myc, Rb-E2F pathways, and the p53 response pathway - is fundamental to the control of cells moving from quiescence through G1 and into S phase, and link the activity of the cellular proliferation process with the determination of cell fate. Myriad aspect of deregulation of these pathways relate to the development of human cancer. The DICBP is developing genomic-scale measures of gene expression, sequence, metabolic and protein data whose analysis and interpretation will underlie the development of a comprehensive understanding of the complex regulatory networks that involves these pathways. The Program is a cohesive program involving a multi-disciplinary team of investigators, and integrates the development of biological investigation with the development and application of statistical models and computational tools for the analysis of such data. |
| Integratvie Cancer Biology Program |
