| Marc
Vidal, Ph.D., Associate Professor of Genetics at Dana-Farber Cancer
Institute, has focused much of his work on understanding protein
networks. As a model for investigating protein networks in development,
Dr. Vidal and his team cloned the first version of the complete
set of C. elegans protein-encoding ORFeomes (ORF) and generated
the first map of protein-protein interaction (interactome) for a
multicellular organism. Through this work, they have learned how
to gather and organize large-scale data sets for first pass protein
interaction mapping, and are beginning to learn how to integrate
different functional genomic and proteomic datasets in maps into
functional wiring diagrams. In addition, they have developed technologies
to precisely test the function of particular interactions using
reagents that disassociate or prevent those interactions. |
Human ORFeome Project |
Human Interactome Project |
