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CCSB researchers created a map linking different diseases, represented by circles, to the genes they have in common, represented by squares.
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NHGRI Funds Two Centers of Excellence in Genomic Science |
The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), today announced grants expected to total approximately $30 million to establish one new Center of Excellence in Genomic Science at the Dana-Farber Cancer Institute (DFCI), and continue its support of the center at Stanford University.
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Salehi-Ashtiani K, Yang X, Derti A, Tian W, Hao T, Lin C, Makowski K, Shen L, Murray RR, Szeto D, Tusneem N, Smith DR, Cusick ME, Hill DE, Roth FP, Vidal M. Isoform discovery by targeted cloning, 'deep-well' pooling and parallel sequencing. Nat Methods 2008;5:597-600.
Describing the ORFeome of an organism, including all major
isoforms, is essential for a system-level understanding of
any species; however, conventional cloning and sequencing
approaches are prohibitively costly and labor-intensive..MORE->>> |
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Djebali S, Kapranov P, Foissac S, Lagarde J, Reymond A, Ucla C, Wyss C, Drenkow J, Dumais E, Murray RR, Lin C, Szeto D, Denoeud F, Calvo M, Frankish A, Harrow J, Makrythanasis P, Vidal M, Salehi-Ashtiani K, Antonarakis SE, Gingeras TR, Guigo R. Efficient targeted transcript discovery via array-based normalization of RACE libraries. Nat Methods 2008;5:629-35.
Rapid amplification of cDNA ends (RACE) is a widely used approach for transcript identification. Random clone selection from the RACE mixture, however, is an ineffective sampling strategy if the dynamic range of transcript abundances is large.MORE->>>
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Center for Cancer Systems Biology (CCSB)
Presents
Candidate Gene Prioritization by Genomic Data Fusion
Yves Moreau
SymBioSys Center for Computational Systems Biology
University of Leuven (ESAT-SCD), Belgium
Monday July 28, 2008
11:00 AM
SM860
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