Dana-Farber Cancer Institute (DFCI)  | Dept of Cancer Biology (DFCI)  | Harvard Medical School (HMS)  | Dept of Genetics (HMS)     

Center for Cancer Systems Biology (CCSB)

at Dana-Farber Cancer Institute, Boston MA

Greetings from Dr Marc Vidal, Director


The long-term goal of CCSB is to understand how macromolecular networks control biological processes and how perturbations in such networks can explain phenotypes and human disease.

Physical protein-protein interactions are instrumental for all biological processes. We address fundamental questions regarding protein interactions. How are protein interactions organized at the scale of the whole cell? Are there global principles that organize such complex networks of interactions? What are the global topological features of networks and what do they mean? And how is the organization of cellular networks disrupted in human disease? (Flyer Summarizing CCSB Objectives)

To determine how proteins function in complex cellular networks we engage in “interactome” modeling, the mapping and systematic characterization of protein-protein interactions at proteome scale (Vidal FEBS Lett 2005; Cusick et al Hum Mol Genet 2005; Barabási et al Nat Rev Genet 2011; Vidal et al Cell 2011; Carvunis et al Handbook Syst Biol 2012). The initial focus on the multicellular model organism Caenorhabditis elegans has since been extended to other model organisms, the yeast Saccharomyces cerevisiae, the plant Arabidopsis thaliana, the fly Drosophila melanogaster, and particularly human, as well as to interactions between viral and host proteins.

Recent Achievements

CCSB Research

  • Network Biology
    How network properties relate to biology and disease, using experimental and theoretical approaches

  • Interactome
    Development and use of high-throughput technologies to map protein-protein interaction networks of H. sapiens and model organisms



News & Events

An inter-species protein–protein interaction network across vast evolutionary distance.

Mol Syst Biol. 2016 April 22; 12(4):865.

Dataset of the month: May
IntAct database, EMBL-EBI

Survey of variation in human transcription factors reveals prevalent DNA binding changes

Science. 2016 Mar 25; 351(6280):1450-4

Harvard Catalyst Introduction to Network Medicine

Speaker: David E. Hill, PhD

May 2 - 4, 2016

CCSB/PSB 2016 Retreat

Beauport Hotel Gloucester, MA

September 7 - 9, 2016




Core Members

Marc Vidal
Director, CCSB
Dana-Farber Cancer Institute

László Barabási
Northeastern University

Juan Fuxman Bass
Boston University

Jennifer Benanti
UMass Medical School

Robert C. Brewster
UMass Medical School

Martha Bulyk
Harvard Medical School

Job Dekker
UMass Medical School

Suzanne Gaudet
Dana-Farber Cancer Institute

Sasha Gimelbrant
Dana-Farber Cancer Institute

Mike Lee
UMass Medical School

Amir Mitchell
UMass Medical School

Chad Myers
University of Minnesota

Art Pardee
Dana-Farber Cancer Institute

Fritz Roth
 University of Toronto

Dan Silver
Thomas Jefferson University

Marian Walhout
UMass Medical School

Brandon Xia
McGill University


2003 - © CCSB - Center for Cancer Systems Biology DFCI - Dana-Faber Cancer Institute Print version  Accessible Version