Center for Cancer Systems Biology - CCSB

CCSB_Retreat

CCSB Retreat, September 2012, Gloucester, MA

CCSB consists of several interdependent lines of research to systematically study systems biology. ORFeome projects aim to comprehensively identify protein coding ORFs and their splice isoforms, capturing these as Gateway compatible Entry clones. Interactome projects use these Entry clones for large-scale binary interactome mapping. The interactome maps so produced are instrumental for network analysis, for studying the effects of disease-associated missense mutations on cellular networks, and for dissecting the effects pathogen proteins have on the cellular networks. These types of questions are addressed by Network Biology analyses. Pathogen Host Interactome mapping projects analyze how viral and bacterial proteins intersect with their host networks. All activities are supported by a Bioinformatics core.

(Overview Flyer)

CCSB is a highly interactive and collaborative environment. CCSB Core Members have expertise in diverse areas of systems biology. CCSB Seminars (CCSB Seminar Schedule, Spring 2013) and the annual CCSB Retreat provide forums for exchange and discussion, and have crystallized many interdisciplinary and collaborative research projects.