Dana-Farber Cancer Institute (DFCI)  | Dept of Cancer Biology (DFCI)  | Harvard Medical School (HMS)  | Dept of Genetics (HMS)     

Center for Cancer Systems Biology - CCSB



CCSB Retreat, September 2012, Gloucester, MA 

The core research at CCSB proceeds along several interdependent lines to systematically study systems biology. ORFeome projects aim to comprehensively identify protein coding ORFs and their splice isoforms and their disease-related polymorphisms, capturing these as Gateway compatible Entry clones. ORF clones are freely available to the research community. Interactome projects use these Entry clones for large-scale binary interactome mapping for multiple model organisms. The interactome maps so produced are instrumental for network analysis, for studying the effects of disease-associated missense mutations on cellular networks, and for dissecting the effects pathogen proteins have on the cellular networks. These types of questions are addressed by Network Biology analyses. Pathogen Host Interactome mapping projects analyze how viral and bacterial proteins intersect with their host networks. All activities are supported by a Bioinformatics core.

(Overview Flyer)

CCSB operates as a "center without walls", engaging in numerous collaborative efforts in Boston and beyond in a highly interactive environment. The key to the center without walls are the CCSB Core Members, who share deep expertise in diverse areas of systems biology. CCSB Seminars and the annual CCSB Retreat provide forums for exchange and discussion, and have crystallized many interdisciplinary and collaborative research projects. The progress that has been achieved, and the promise for the future, was recently celebrated at the CCSB 10th Anniversary Symposium.


CCSB 2012 Accomplishments


CCSB 2011 Accomplishments






Core Members

Marc Vidal
Director, CCSB
Dana-Farber Cancer Institute

László Barabási
Northeastern University

Martha Bulyk
Harvard Medical School

Job Dekker
UMass Medical School

Suzanne Gaudet
Dana-Farber Cancer Institute

Sasha Gimelbrant
Dana-Farber Cancer Institute

Mike Lee
UMass Medical School

Art Pardee
Dana-Farber Cancer Institute

Fritz Roth
 University of Toronto

Dan Silver
Dana-Farber Cancer Institute

Marian Walhout
UMass Medical School

Brandon Xia
McGill University


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