Dana-Farber Cancer Institute (DFCI)  | Dept of Cancer Biology (DFCI)  | Harvard Medical School (HMS)  | Dept of Genetics (HMS)     

Center for Cancer Systems Biology - CCSB

 

CCSB_Retreat

CCSB Retreat, September 2012, Gloucester, MA 

CCSB pursues several interdependent lines of research to systematically study systems biology. ORFeome projects aim to comprehensively identify protein coding ORFs and their splice isoforms, capturing these as Gateway compatible Entry clones. Interactome projects use these Entry clones for large-scale binary interactome mapping. The interactome maps so produced are instrumental for network analysis, for studying the effects of disease-associated missense mutations on cellular networks, and for dissecting the effects pathogen proteins have on the cellular networks. These types of questions are addressed by Network Biology analyses. Pathogen Host Interactome mapping projects analyze how viral and bacterial proteins intersect with their host networks. All activities are supported by a Bioinformatics core.

(Overview Flyer)

CCSB is a highly interactive and collaborative environment. CCSB Core Members have expertise in diverse areas of systems biology. CCSB Seminars (CCSB Seminar Schedule, Spring 2013) and the annual CCSB Retreat provide forums for exchange and discussion, and have crystallized many interdisciplinary and collaborative research projects.

 

CCSB 2012 Accomplishments

CCSB_Retreat

CCSB 2011 Accomplishments

 

 


 

 

 

Core Members

Marc Vidal
Director, CCSB
Dana-Farber Cancer Institute

László Barabási
Northeastern University

Martha Bulyk
Harvard Medical School

Job Dekker
UMass Medical School

Suzanne Gaudet
Dana-Farber Cancer Institute

Sasha Gimelbrant
Dana-Farber Cancer Institute

Mike Lee
UMass Medical School

Art Pardee
Dana-Farber Cancer Institute

Fritz Roth
 University of Toronto

Dan Silver
Dana-Farber Cancer Institute

Marian Walhout
UMass Medical School

Brandon Xia
McGill University

 

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