Center for Cancer Systems Biology - CCSB

CCSB has grown out of the Vidal lab and now consists of several independent, interdependent research groups working closely together to study network biology. The ORFeome group aims at comprehensively identifying protein coding ORFs and their splice isoforms, and capturing those as Gateway compatible entry clones. The Interactome group uses those entry clones for large-scale binary interactome mapping. The so produced maps are instrumental for network analysis, for studying the effects of disease associated missense mutations on network level and for dissecting the effects pathogen proteins have on the network. Those and other types of questions are addressed by the Network Biology Group (Vidal lab). The Pathogen Host mapping projects analyze how viral and bacterial proteins intersect with their host networks. All activities are supported by the bioinformatics group.

CCSB is a highly interactive and collaborative environment and CCSB's Associate Members have expertise in very diverse areas of systems biology. The bimonthly ThinkTank meetings, regular Seminars and the annual CCSB retreat provide forums for exchange and discussion, and have crystallized many interdisciplinary research projects.