Dana-Farber Cancer Institute (DFCI)  | Dept of Cancer Biology (DFCI)  | Harvard Medical School (HMS)  | Dept of Genetics (HMS)     

Center for Cancer Systems Biology - CCSB



CCSB Retreat, September 2015, Gloucester, MA 

The core research at CCSB proceeds along several interdependent lines to systematically study systems biology. ORFeome projects aim to comprehensively identify protein coding ORFs and their splice isoforms and their disease-related polymorphisms, capturing these as Gateway compatible Entry clones. ORF clones are freely available to the research community. Interactome projects use these Entry clones for large-scale binary interactome mapping for multiple model organisms. The interactome maps so produced are instrumental for network analysis, for studying the effects of disease-associated missense mutations on cellular networks, and for dissecting the effects pathogen proteins have on the cellular networks. These types of questions are addressed by Network Biology analyses. Pathogen Host Interactome mapping projects analyze how viral and bacterial proteins intersect with their host networks. All activities are supported by a Bioinformatics core.




News & Events

An inter-species protein–protein interaction network across vast evolutionary distance.

Mol Syst Biol. 2016 April 22; 12(4):865.

Dataset of the month: May
IntAct database, EMBL-EBI

Survey of variation in human transcription factors reveals prevalent DNA binding changes

Science. 2016 Mar 25; 351(6280):1450-4

Harvard Catalyst Introduction to Network Medicine

Speaker: David E. Hill, PhD

May 2 - 4, 2016

CCSB/PSB 2016 Retreat

Beauport Hotel Gloucester, MA

September 7 - 9, 2016




Core Members

Marc Vidal
Director, CCSB
Dana-Farber Cancer Institute

László Barabási
Northeastern University

Juan Fuxman Bass
Boston University

Jennifer Benanti
UMass Medical School

Robert C. Brewster
UMass Medical School

Martha Bulyk
Harvard Medical School

Job Dekker
UMass Medical School

Suzanne Gaudet
Dana-Farber Cancer Institute

Sasha Gimelbrant
Dana-Farber Cancer Institute

Mike Lee
UMass Medical School

Amir Mitchell
UMass Medical School

Chad Myers
University of Minnesota

Art Pardee
Dana-Farber Cancer Institute

Fritz Roth
 University of Toronto

Dan Silver
Thomas Jefferson University

Marian Walhout
UMass Medical School

Brandon Xia
McGill University


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