Greetings from Dr Marc Vidal, Director
The long-term goal of CCSB is to understand how macromolecular networks control biological processes and how perturbations in such networks can explain phenotypes and human disease.
Physical protein-protein interactions are instrumental for all biological processes. We address fundamental questions regarding protein interactions. How are protein interactions organized at the scale of the whole cell? Are there global principles that organize such complex networks of interactions? What are the global topological features of networks and what do they mean? And how is the organization of cellular networks disrupted in human disease? (Flyer Summarizing CCSB Objectives)
To determine how proteins function in complex cellular networks we engage in “interactome” modeling, the mapping and systematic characterization of protein-protein interactions at proteome scale (Vidal FEBS Lett 2005; Cusick et al Hum Mol Genet 2005; Barabási et al Nat Rev Genet 2011; Vidal et al Cell 2011; Carvunis et al Handbook Syst Biol 2012). The initial focus on the multicellular model organism Caenorhabditis elegans has since been extended to other model organisms, the yeast Saccharomyces cerevisiae, the plant Arabidopsis thaliana, the fly Drosophila melanogaster, and particularly human, as well as to interactions between viral and host proteins.
Experimental definition of open reading frames (ORFs) and splice isoforms for H. sapiens and model organisms
- Pathogen-Host Interactomes
Investigations of how proteins of pathogens interact with and perturb host interactomes (CCSB Center of Excellence in Genomic Sciences (CEGS))