Dana-Farber Cancer Institute (DFCI)  | Dept of Cancer Biology (DFCI)  | Harvard Medical School (HMS)  | Dept of Genetics (HMS)     

2015 Publications 

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 Multiplex-interaction-profiling Sharma A, Menche J, Huang C, Ort T, Zhou X, Kitsak M, Sahni N, Thibault D, Voung L, Guo F, Gulbahce N, Baribaud F, Tocker J, Dobrin R, Barnathan E, Liu H, Panettieri RA Jr, Tantisira KG, Qiu W, Raby BA, Silverman EK, Vidal M, Weiss ST, Barabási AL.
A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes.
Hum Mol Genet2015; 24:3005-20.
 
 Multiplex-interaction-profiling Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kovács IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barabási A-L, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJ, Lindquist S and Vidal M.
Widespread macromolecular interaction perturbations in human genetic disorders.
Cell 2015; 161:647-60.
 
 Multiplex-interaction-profiling Fuxman Bass JI, Sahni N, Shrestha S, Garcia-Gonzalez A, Mori A, Bhat N, Yi S, Hill DE, Vidal M and Walhout AJ.
Human gene-centered transcription factor networks for enhancers and disease variants.
Cell 2015; 161:661-73.
 
 Multiplex-interaction-profiling Yang F, Petsalaki E, Rolland T, Hill DE, Vidal M, Roth FP.
Protein domain-level landscape of cancer-type-specific somatic mutations.
PLoS Comput Biol 11:e1004147.
 
 Multiplex-interaction-profiling Menche J, Sharma A, Kitsak M, Ghiassian SD, Vidal M, Loscalzo J, Barabási AL.
Uncovering disease-disease relationships through the incomplete interactome.
Science 2015; 347:1257601.
 
 
 Multiplex-interaction-profiling Lin GN, Corominas R, Lemmens I, Yang X, Tavernier J, Hill DE, Vidal M, Sebat J, Iakoucheva LM.
Spatiotemporal 16p11.2 protein network implicates cortical late mid-fetal brain development and KCTD13-Cul3-RhoA pathway in psychiatric diseases.
Neuron 2015; 85:742-54.
 
 Multiplex-interaction-profiling Taşan M, Musso G, Hao T, Vidal M, MacRae CA, Roth FP.
Selecting causal genes from genome-wide association studies via functionally coherent subnetworks.
Nat Methods 2015; 12:154-9.
 
 

 

 

 

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