Dana-Farber Cancer Institute (DFCI)  | Dept of Cancer Biology (DFCI)  | Harvard Medical School (HMS)  | Dept of Genetics (HMS)     

2014 Publications 

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 Human-Interactome Rolland T, Tasan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian S, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis A-R, Convery-Zupan D, Corominas R, Hardy M, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere J, Vega K, Walsh J, Cusick ME, Xia Y, Barabasi A-L, Iakoucheva L, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP, Vidal M.
A proteome-scale map of the human interactome network.
Cell 2014; 159:1212-1226.
 
 
 Multiplex-interaction-profiling Gu L, Li C, Aach J, Hill DE, Vidal M, Church GM.
Multiplex single-molecule interaction profiling of DNA-barcoded proteins.
Nature 2014; 515:554-7.
 
 Chaperome-subnetwork Brehme M, Voisine C, Rolland T, Wachi S, Soper JH, Zhu Y, Orton K, Villella A, Garza D, Vidal M, Ge H, Morimoto RI.
A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease.
Cell Reports 2014; 3:1135-1150.
 
 Virus-Host-three-kingdoms Wessling R, Epple P, Altmann S, He Y, Yang L, Henz SR, McDonald N, Wiley K, Bader KC, Glasser C, Mukhtar MS, Haigis S, Ghamsari L, Stephens AE, Ecker JR, Vidal M, Jones JD, Mayer KF, Ver Loren van Themaat E, Weigel D, Schulze-Lefert P, Dangl JL, Panstruga R, Braun P.
Convergent targeting of a common host protein-network by pathogen effectors from three kingdoms of life.
Cell Host Microbe 2014; 16:364-375.
 
 BRCA1-transcription Hill SJ, Rolland T, Adelmant G, Xia X, Owen MS, Dricot A, Zack TI, Sahni N, Jacob Y, Hao T, McKinney KM, Clark AP, Reyon D, Tsai SQ, Joung JK, Beroukhim R, Marto JA, Vidal M, Gaudet S, Hill DE, Livingston DM.
Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.
Genes Dev 2014; 28:1957-1975.
 
 Variome-Virome Zhou X, Menche J, Barabási AL, Sharma A.
Human symptoms-disease network.
Nat Commun 2014; 5:4212.
 
 Variome-Virome Wang W, Zhong Q, Teng L, Bhatnagar N, Sharma B, Zhang X, Luther W 2nd, Haynes LP, Burgoyne RD, Vidal M, Volchenboum S, Hill DE, George RE.
Mutations that disrupt PHOXB interaction with the neuronal calcium sensor HPCAL1 impede cellular differentiation in neuroblastoma.
Oncogene 2014; 33:3316-24.
 
 Variome-Virome Xia X, Owen MS, Lee RE, Gaudet S.
Cell-to-cell variability in cell death: can systems biology help us make sense of it all?
Cell Death Dis 2014; 5:e1261.
 
  Dittmer TA, Sahni N, Kubben N, Hill DE, Vidal M, Burgess RC, Roukos V, Misteli T.
Systematic identification of pathological lamin A interactors.
Mol Biol Cell 2014; 25:1493-510.
 
 Variome-Virome Adamia S, Bar-Natan M, Haibe-Kains B, Pilarski PM, Bach C, Pevzner S, Calimeri T, Avet-Loiseau H, Lode L, Verselis S, Fox EA, Galinsky I, Mathews S, Dagogo-Jack I, Wadleigh M, Steensma DP, Motyckova G, Deangelo DJ, Quackenbush J, Tenen DG, Stone RM, Griffin JD.
NOTCH2 and FLT3 gene mis-splicing are common events in patients with acute myeloid leukemia (AML): new potential targets in AML.
Blood 2014; 123:2816-25.
 
  Deville P, Wang D, Sinatra R, Song C, Blondel VD, Barabási AL.
Career on the move: geography, stratification, and scientific impact.
Sci Rep 2014; 4:4770.
 
  Corominas R, Yang X, Lin GN, Kang S, Shen Y, Ghamsari L, Broly M, Rodriguez M, Tam S, Trigg SA, Fan C, Yi S, Tasan M, Lemmens I, Kuang X, Zhao N, Malhotra D, Michaelson JJ, Vacic V, Calderwood MA, Roth FP, Tavernier J, Horvath S, Salehi-Ashtiani K, Korkin D, Sebat J, Hill DE, Hao T, Vidal M, Iakoucheva LM.
Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
Nat Commun 2014; 5:3650.
 
  Cokol M, Weinstein ZB, Yilancioglu K, Tasan M, Doak A, Cansever D, Mutlu B, Li S, Rodriguez-Esteban R, Akhmedov M, Guvenek A, Cokol M, Cetiner S, Giaever G, Iossifov I, Nislow C, Shoichet B, Roth FP.
Large-scale identification and analysis of suppressive drug interactions.
Chem Biol 2014; 21:541-51.
 
 
 Variome-Virome Lee RE, Walker SR, Savery K, Frank DA, Gaudet S.
Fold change of nuclear NF-κB determines TNF-induced transcription in single cells.
Mol Cell 2014; 53:867-79.
 
 
 Variome-Virome Adamia S, Haibe-Kains B, Pilarski PM, Bar-Natan M, Pevzner S, Avet-Loiseau H, Lode L, Verselis S, Fox EA, Burke J, Galinsky I, Dagogo-Jack I, Wadleigh M, Steensma DP, Motyckova G, Deangelo DJ, Quackenbush J, Stone RM, Griffin JD.
A genome-wide aberrant RNA splicing in patients with acute myeloid leukemia identifies novel potential disease markers and therapeutic targets.
Clin Cancer Res 2014; 20:1135-45.
 
 Variome-Virome Musso G, Tasan M, Mosimann C, Beaver JE, Plovie E, Carr LA, Chua HN, Dunham J, Zuberi K, Rodriguez H, Morris Q, Zon L, Roth FP, MacRae CA.
Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish.
Development 2014; 141:224-35.
 
 

 

 

 

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