Studies offer guide as protein interaction mapping comes of age

January 2009

For scientists who track interactions between cell proteins, a time of reckoning has arrived. Over the past 20 years, researchers have identified thousands of such interactions, with the ultimate goal of inventorying all that occur within cells of various organisms — a comprehensive catalogue known as the interactome. Such information will be critical to understanding the basic mechanics of cellular life, and how malfunctions in these processes contribute to cancer.
Unfortunately, the data collected by different teams of researchers has been somewhat inconsistent. One group's "map" of protein interactions in yeast cells, for example, may only partially overlap the map produced by another group. MORE->>>

NHGRI Funds Two Centers of Excellence in Genomic Science

August 2007

BETHESDA, Md., Tues., Aug. 20, 2007 - The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), today announced grants expected to total approximately $30 million to establish one new Center of Excellence in Genomic Science at the Dana-Farber Cancer Institute (DFCI), and continue its support of the center at Stanford University...MORE->>>

Dana-Farber Department of Cancer Biology

April 2007

Today, researchers at the three-year-old Center for Cancer Systems Biology (CCSB), part of the Dana Farber Cancer Institute (DFCI) in Boston, are working toward identifying the high level “wiring diagram” for cancer. In this instance, that means an accurate map of all cancer-associated protein-protein interactions... MORE->>>

New DFCI Center Takes on Lofty Goal of Mapping Complete Set of Gene Interactions within Human Cells

With a draft of the human genome map now in hand, a group of Dana-Farber researchers is moving to the next frontier in molecular research: a study of the interactions among the estimated 30,000 genes in human cells. At DFCI's newly opened Center for Cancer Systems... MORE->>>